Bayesian Double Feature Allocation for Phenotyping with Electronic Health Records

Abstract

We propose a categorical matrix factorization method to infer latent diseases from electronic health records (EHR) data in an unsupervised manner. A latent disease is defined as an unknown biological aberration that causes a set of common symptoms for a group of patients. The proposed approach is based on a novel double feature allocation model which simultaneously allocates features to the rows and the columns of a categorical matrix. Using a Bayesian approach, available prior information on known diseases greatly improves identifiability and interpretability of latent diseases. This includes known diagnoses for patients and known association of diseases with symptoms. We validate the proposed approach by simulation studies including mis-specified models and comparison with sparse latent factor models. In the application to Chinese EHR data, we find that the prevalence of impaired kidney function is slightly higher than the regional average probably due to the elderly patient population. In addition, we discover 10 latent diseases that are related to lipid disorder, thrombocytopenia, polycythemia, anemia, bacterial and viral infections, allergy, and malnutrition. The results are accompanied by a data-assisted personalized diagnosis support system that can facilitate clinicians in medical diagnosis.

Publication
Journal of the American Statistical Association (Applications & Case Studies), 115(532), 1620-1634